According to Documentation, it can happen that the registry key that allows the ConnectWise Control service to start in Safe Mode with Networking, can be removed by Windows 10 update process.
A workaround by reinstalling the access client (or re-adding the registry keys) is mentioned.
The problem here is that this issue becomes evident only AFTER you reboot to Safe Mode and notice the client hasn't connected. In that case, the machine has to be restarted locally.
Since it is not clearly evident whether/when the registry keys have been removed by updating Windows, the only reliable way to prevent this issue from occurring would be to reinstall clients immediately upon updating/upgrading Windows each time.
I suggest a check to be added into the access client itself to check and possibly fix the missing registry keys at each start.
Customer support service by UserEcho