exclude results from search

I'd like to search Summary Description but exclude if a specified word appears.

Example 1 is to search Summary Description for *backup but exclude from results if word successful is included in Summary Description.

Example 2 is to search Summary Description of open tickets for *Quickbooks but exclude if ticket belongs to company ABC 

This would be really helpful in searching a company history with thousands of tickets. Exclude tickets with "backup" in Summary Description, then be able to reduce search results further by excluding word "successful", then reduce search results further by excluding resource "*ah".